Tim Shaw has trouble speaking as a result of motorneuron disease.
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Oxidative stress is commonly implicated in the pathogenesis of motorneuron disease.
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MUNE provides valuable information when applied to animal models of motorneuron disease.
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Murray died on Monday as a result of motorneuron disease.
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Clinical neurophysiology provides markers for upper and lower motorneuron damage.
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Every efferentneuron in his system carried the message full power.
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Our results support the view that heterogeneous chemical profiles account for PPN efferentneurons innervating thalamic targets.
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In this study, we have investigated the presence of leptin receptors in afferent and efferentneurons of the vagus nerve.
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TRPV1 is expressed in some nociceptor efferentneurons, where it acts as a molecular sensor of noxious heat and low pH.
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Using this technique we have investigated the mRNA encoding the trkB receptor for brain-derived neurotrophic factor in identified facial and vestibular afferent and efferentneurons.
Uso de motoneuron em inglês
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The observed motoneuron death was completely prevented by hemoglobin.
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We hypothesized that additional variants could be found in these and novel motoneuron and related diseases.
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Because motoneuron targets in the larva are continuously growing, synaptic contacts are structurally plastic, undergoing continuous expansion.
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Genetic analyses indicate that the muscle is the BMP-sending cell and the motoneuron is the BMP-receiving cell.
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It is frequently encountered after traumatic brain injury or spinal cord injury, rather than lower motoneuron disease.
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However, evaluation of spinal tissue from Pompe patients and animal models indicates glycogen accumulation and lower motoneuron pathology.
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Thus these findings, all together, suggest that a state of early neuronal hyperexcitability may be a major contributor of motoneuron vulnerability.
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Therefore, we analyzed our database of 1024 whole exome sequencing samples of motoneuron and related diseases for novel single nucleotide variations.
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These results indicate that motoneuron excitability changes are observed in the soleus muscle with mechanical conditioning but not with electrocutaneous conditioning.
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These findings suggest that the current MUNIX definition is most suitable for motoneuron diseases that demonstrate secondary evidence of muscle fiber reinnervation.
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In contrast, bath application of 50 microM serotonin produced either depolarizing or hyperpolarizing responses depending on the developmental age of the motoneuron.
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The voxel-based analysis demonstrated varying extents of white matter involvement in different phenotypes of motoneuron disease, albeit in quite similar anatomical locations.
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While motoneuron death is the defining characteristic of ALS, the events that underlie its pathology are not restricted to the nervous system.
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Motor unit number index (MUNIX) measurement has recently achieved increasing attention as a tool to evaluate the progression of motoneuron diseases.
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Three years ago it was reported that reduced levels of vascular endothelial growth factor (VEGF) caused ALS-like motoneuron degeneration in mice.
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In vitro motoneuron-muscle co-cultures are powerful tools to study the role of different growth factors, hormones and cellular structures involved in NMJ formation.